20 Apr 2014
casimir logo Over recent years, the European Commission has supported an increasing number of functional genomics projects focusing on the use of the laboratory mouse as a model of human disease. (see http://www.prime-eu.org/euromouseiiprojects.htm for a fuller listing of current and recent projects). CASIMIR (Coordination and Sustainability of International Mouse Informatics Resources: http://www.casimir.org.uk) is aimed at recommending standards to allow data sharing and integration between the different projects. CASIMIR spans a number of areas: data representation (in particular the use of shared ontologies), non-semantic, technical issues concerning database compatibility and interoperability, data acquisition, curation and ownership, integration of biological collections and material resources into the data network, and user interactions. As part of the CASIMIR initiative i-mouse.org was created as a common portal to CASIMIR and other resources we hope will be helpful for investigators using the mouse as a model system for humans or systems biologists and geneticists using the mouse as an experimental system.

Please browse i-mouse.org by using one of the sections below, which are split up into ontology resources, mouse databases and web services and mouse knockout resources.
Ontology resources for the Community
CASIMIR carried out a survey in summer 2007 to ascertain the sorts of database activities carried out by currently-active EC-funded mouse functional genomics projects and whether they are currently making use of community standards such a ontologies and minimum information standards for reporting experimental data. In a recent paper we report the results of the survey and discuss their consequences in the context of integration of these large projects into the wider data network. More...

One issue arising from this consultation was the perceived need for a resource listing relevant ontologies for mouse functional genomics and i-mouse.org was created as a resource to address this need. Link to Ontology Resources page

Mouse Resource Browser (MRB)
The MRB comprises a database of data and information resources of use to those interested in the biology and genetics of the laboratory mouse. Integration of data across many of these resources requires knowledge of the technical details of data structure and programmatic access, for example, and in addition to descriptions of the databases, URLs and links, we will bring together technical details to facilitate the construction of automatic work flows and data feeds. More...
Mouse knockout resources


EUCOMM

The goal of EUCOMM is to generate collection of up to 20,000 mutated genes in mouse embryonic stem (ES) cells using conditional gene trapping and gene targeting approaches which will be made available to investigators world wide.
Main web page.
Pipeline status page.

KOMP

KOMP is a trans-NIH initiative to generate a public resource of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome. Two groups have been funded by this program to generate knockout mouse lines: Regeneron Pharmaceuticals, Inc. and a collaborative team at the Children's Hospital Oakland Research Institute (CHORI), the University of California at Davis School of Veterinary Medicine, and the Wellcome Trust Sanger Institute.
Main web page.
Pipeline status page.

NorCOMM

NorCOMM (North American Conditional Mouse Mutagenesis project) is a large-scale research initiative focused on developing and distributing a library of mouse embryonic stem (ES) cell lines carrying single conditional knockout mutations across the mouse genome.
Main web page.